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2010-06-09 2010 ASCO (America Society of Clinical Oncology) - Abstract 4678 - Safety
S. Nilsson, C. Parker, I. Haugen, A. Lokna, A.K. Aksnes, B. Bolstad, G. O’Bryan-Tear, Ø.S. Bruland: Radium-223 Chloride, a First-in-Class Alpha-Pharmaceutical With a Benign Safety Profile for Patients With Castration-Resistant Prostate Cancer (CRPC) and Bone Metastases: Combined Analysis of Phase I and II Clinical Trials
2010-04-19 The Lancet Oncology: Radomized double blind placebo controlled phase II trial in HRPC – initial results:
Nilsson S, Franzen L, Parker C, Tyrrell C, Blom R, Tennvall J et al.: Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: a randomised, multicentre, placebo-controlled phase II study. Lancet Oncol 2007 July;8(7):587-94.
2010-04-09 2010 ASCO GU (The American Society of Clinical Oncology, Genitourinary Cancers Symposium) – Safety profile
Nilssen et al: Alpharadin, a novel, highly targeted alpha pharmaceutical with a good safety profile for patients with CRPC and bone metastases: Combined analyses of phase I and II clinical trials. 2010 Genitourinary Cancers Symposium
2010-01-08 Dahle, J
Dahle, J. et al. Initial evaluation of 227Th-p-benzyl-DOTA-rituximab for low-dose rate alpha-particle radioimmunotherapy Nuclear Medicine and Biology 33 (2006), 271-279
2010-04-09 2010 ASCO GU (The American Society of Clinical Oncology, Genitourinary Cancers Symposium)
Lewington et al: Alpharadin: A novel, targeted approach for treatment of bone metastases from CRPC-calculated alpha-particle dosimetry compared to a favorable clinical safety profile. 2010 Genitourinary Cancers Symposium
2010-04-09 2010 ASCO GU (The American Society of Clinical Oncology, Genitourinary Cancers Symposium)
Morris et al: Phase I pharmacokinetic (PK) and biodistribution study with escalating doses of radium-223 in men with castration-resistant metastatic prostate cancer (CRMPC). 2010 Genitourinary Casncers Symposium.
2010-04-19 2009 15th ECCO (European Cancer Conference), BC1-02 poster: Radomized double blind placebo controlled phase II trial in HRPC – follow-up data:
Nilsson S, Franzen L, Parker C, Bolstad B, Ramdahl T, Thuresson M. and Ø.S. Bruland: Alpha-emitting Radium-223: Two years follow up from a randomized phase II study in patients with bone metastases from hormone refractory prostate cancer.
2010-04-19 2009 15th ECCO (European Cancer Conference), BC1-03 poster: Results from a dedicated pain palliation trial:
Nilsson S, Strang P, Franzén L, Olivier P, Pecking A, Staffurth J, Vasanthan S, Andersson C, Bruland Ø.S and A.K. Aksnes: A double-blind, randomised dose-response phase II, multicentre study of radium-223 (Alpharadin®) for the palliation of painful bone metastases in castration-refractory prostate cancer patients.
2010-01-08 2007 ASCO Annual Meeting (The American Society of Clinical Oncology)
S. Nilsson et al.: Radium-223 in the treatment of metastatic hormone refractory prostate cancer (HRPC). Results from a randomized, placebo-controlled, phase 2 study.
2010-01-08 2007 ASCO Prostate Cancer Symposium (The American Society of Clinical Oncology)
S. Nilsson et al.: A Randomized, Placebo-Controlled, Phase 2 Study of Radium-223 in the Treatment of Metastatic Hormone Refractory Prostate Cancer (HRPC). Twelve Months Follow-Up Data.
2010-01-08 2007 14th ECCO (European Cancer Conference)
S. Nilsson et al.: Placebo-Controlled, Randomized, Phase II Study of Radium-223 in Metastatic Hormone Refractory Prostate Cancer (HRPC)
2010-01-08 2006 Prostate Cancer Foundation 13th Scientific Retreat: Algeta’s Alpharadin™ reduces PSA levels significantly in a placebo-controlled trial in prostate cancer patients
S. Nilsson et al.: Double-Blind, Placebo-Controlled Trial of Radium-223 Adjuvant to External Beam Radiotherapy Demonstrates Significant Decline in Bone-Alkaline Phosphatase and PSA in Patients with Hormone Refractory Prostate Cancer (HRPC).